Real-World Betaseron Health Economic Outcomes Study for Relapsing Forms of Multiple Sclerosis

Inclusion Criteria: * Provides written informed consent to participate in the study * At least 18 but no more than 65 years old * Documented clinical diagnosis of a relapsing form of multiple sclerosis or confirmed clinically isolated syndrome (CIS) * Initiating Betaseron therapy, or resuming Betaseron after not having used it for at least three months * Willing and able to provide a valid e-mail address which will be in use for the duration of the study * Willing and able to complete study questionnaires via the Internet * Has reliable Internet access for the duration of the study * Completes the baseline patient questionnaire Exclusion Criteria: * Kurtzke Expanded Disability Status Scale (EDSS) score greater than 6.0 * Cognitive dysfunction that, in the Investigator's judgment, raises doubts about the study participant's ability to provide informed consent or accurately complete the monthly patient questionnaire * Any use of Betaseron within the three months prior to study entry * Inability to read, write, or speak the English language * Illness or disease other than multiple sclerosis that the Investigator believes is likely to cause the patient's death or incapacity within twelve months * Any severe, uncontrolled illness or condition that the Investigator believes could dominate the patient's quality of life * Coexistent autoimmune disease such as rheumatoid arthritis, lupus, or psoriasis that is likely to be exacerbated by treatment with Interferon * Current use of any immunosuppressive medication * Previous participation in a multiple sclerosis (MS) clinical trial within the three months prior to study entry * Previous use of monoclonal antibodies treating MS within the three months prior to study entry * Current use of any secondary treatment for multiple sclerosis other than the episodic use of steroids during relapses or exacerbations