Effect of Preoperative Pregabalin on Propofol Induction Dose

Université de Sherbrooke50 enrolled

Overview

The primary issue is to determine whether preoperatively administered pregabalin decreases the necessary dose of propofol during induction of general anesthesia. The investigators secondary issue is to test if preoperatively administered pregabalin decreases anxiety.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Anesthesia, General Laparoscopic Surgery

Interventions

PregabalinDRUG

Preoperative administration of pregabalin vs placebo 1 hour before surgery

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Laparoscopic gynaecologic surgery * Age 18-40 years * ASA class I or II * Body mass index 18-30 Exclusion Criteria: * Allergic to pregabalin or gabapentin * Chronic renal failure * Alcohol or drug abuse * Chronic analgesic use other than acetaminophen or NSAID * Already taking gabapentin, pregabalin, benzodiazepin or antidepression drug * Known neurological deficiency * Suspected difficult intubation or ventilation * Atypical pseudocholinesterases

Locations (1)

Centre Hospitalier Universitaire de Sherbrooke

Sherbrooke, Quebec, Canada

Outcomes

Primary Outcomes

Propofol induction dose

Evaluation of the hpreoperative pregabalin Vs placebo effect on propofol induction dose needed to induce general anesthesia assessed by entropy in gynaecologic patients undertaking minor surgical procedure.

Time frame: 1 hour

Secondary Outcomes

Preoperative anxiety

Evaluation of the effect of pregabalin Vs placebo on preoperative anxiety

Time frame: 1 hour

Data from ClinicalTrials.gov

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