LBH589 Oral in Combination With Carboplatin and Paclitaxel in Advanced Solid Tumors

Inclusion Criteria: 1. Histological/cytological diagnosis of solid tumors in which treatment with Carboplatin and Paclitaxel is indicated, e.g. NSCLC, GY tumors, prostate cancer, unknown primary 2. Progressive disease (also in terms of tumor markers only, like CA 125 for ovary and PSA for prostate). 3. Age 18-75 years 4. Prior chemotherapy of ≤ 1 line for advanced disease 5. ECOG Performance Status \< 2 6. Life expectancy of at least 3 months 7. The patient must be able to read, understand and provide written evidence of informed consent 8. Female patients may not be pregnant or lactating and must be willing to practice contraception. The effects of LBH589 on the developing human fetus are unknown. For this reason, women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for the duration of study participation. 9. Male patients that are not surgically sterile must be practicing a medically acceptable contraceptive regimen while on study treatment 10. Adequate organ function as defined by the following: * ANC \> 1500/µL * Platelets ≥ 100,000/µL * Haemoglobin ≥ 10 g/dl * Serum creatinine ≤ 1.5 x ULN or 24-hour creatinine clearance ≥ 60 ml/min * Magnesium, potassium and phosphorus ≥ the lower limit of normal or correctable with supplements * Aspartate aminotransferase (AST/SGOT) and alanine aminotransferase (ALT/SGPT) ≤ 2.5 x ULN or ≤ 5.0 x ULN if hepatic involvement is present * Serum bilirubin ≤ 1.5 x ULN * Alkaline phosphatase (ALP) ≤ 2.5 x ULN or ALP \> 2.5 x UNL with liver fraction ≤ 2.5 x ULN Exclusion Criteria: 1. Other chemotherapy treatment \< 4 weeks prior to enrolment 2. Hypersensitivity or allergic reactions to platinum compounds or Carboplatin®; hypersensitivity or allergic reactions to Paclitaxel 3. Radiotherapy involving \> 30% of the active bone marrow 4. Radiotherapy \< 4 weeks prior to enrolment 5. Pre-existing peripheral neuropathy ≥ grade 2 6. Pre-existing CTCAE hearing loss or tinnitus ≥ grade 2 7. Symptomatic pleural effusion 8. Clinically significant third space fluid accumulation (e.g. ascites,..) 9. Symptomatic brain metastasis or meningeal tumors 10. Patients who have not recovered (\> grade 1) from the following toxicities of previous regimens before enrolment: fatigue, mucositis, nausea/vomiting, diarrhea 11. Concurrent enrolment, or previous enrolment within 30 days prior to registration in another investigational device or drug trial(s) or is receiving other investigational agent(s) 12. Human immunodeficiency virus (HIV) infection 13. History of bone marrow or major organ transplant 14. Prior high dose treatment with PBSC support 15. Impaired cardiac function, including any one of the followings: * Complete Left Bundle Branch Block or obligate use of a cardiac pacemaker or congenital long QT syndrome or history or presence of atrial or ventricular tachyarrhythmias or clinically significant resting bradycardia (\< 50 beats per minute) or QTcF \> 480 msec on screening ECG or Right Bundle Branch block + left anterior hemiblock (bifascicular block) * Angina pectoris or acute MI ≤ 3 months prior to starting study drug * Other clinically significant heart disease (e.g. congestive heart failure, uncontrolled hypertension, history of labile hypertension, or history of poor compliance with an antihypertensive regimen) 16. Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral LBH589 (e.g., ulcerative diseases, uncontrolled nausea, vomiting, malabsorption syndrome, or small bowel resection) 17. Acute or chronic liver or renal disease 18. Other concurrent severe and/or uncontrolled medical conditions (e.g., uncontrolled diabetes, active or uncontrolled infection, chronic obstructive or chronic restrictive pulmonary disease) that could cause unacceptable safety risks or compromise compliance with the protocol 19. Concomitant use of CYP3A4/5 inhibitors or inducers where the treatment can not be discontinued or switched to a different medication prior to starting study drug (medications listed in Appendix 3). The medications listed in Appendix 3 have a relative risk of prolonging the QT interval or inducing Torsades de Pointes, but do not represent an exclusion criteria 20. Treatment with any hematopoietic colony-stimulating growth factors (e.g., G-CSF, GMCSF) ≤ 2 weeks prior to starting study drug. 21. Treatment with therapeutic doses of sodium warfarin (Coumarin ). Low doses of Coumarin (e.g., ≤ 2 mg/day) for line patency is allowable 22. Patients who have received biologic therapy (excluding antiangiogenics) or immunotherapy ≤ 2 weeks prior to starting study treatment or who have not recovered from side effects of such therapy 23. Patients who have undergone major surgery ≤ 2 weeks prior to starting study drug or who have not recovered from side effects of such therapy 24. Unable or unwilling to comply with all study procedures 25. Current history of alcohol or drug abuse