A Study to Evaluate the Safety, Reactogenicity and Immunogenicity of GSK Biologicals' Staphylococcal Investigational Vaccine in Healthy Adults

Inclusion Criteria: * Subjects who the investigator believes can and will comply with the requirements of the protocol. * A male or female between 18 and 40 years of age, inclusive, at the time of first vaccination. * Written informed consent obtained from the subject. * Healthy subjects as established by medical history, clinical examination and laboratory assessment before entering into the study. * Female subjects of non-childbearing potential may be enrolled in the study. * Female subjects of childbearing potential may be enrolled in the study, if the subject: * has practiced adequate contraception for 30 days prior to vaccination, and * has a negative pregnancy test at Screening, and * has agreed to continue adequate contraception during the entire treatment period and for 2 months after completion of the vaccination series Exclusion Criteria: * Use of any investigational or non-registered product other than the study vaccines within 30 days preceding the first dose of study vaccine, or planned use during the study period. * Chronic administration of immunosuppressants or other immune-modifying drugs within 6 months prior to the first vaccine dose. * Any clinically significant acute or chronic, local or systemic infection, proven or suspected to be caused by Staphylococcus aureus and requiring antibiotic treatment, within the 6 months preceding the first vaccination. * Previous administration of any investigational Staphylococcus aureus vaccine/antibodies. * History of; or current bleeding or coagulation disorder. * Known or suspected reaction or hypersensitivity likely to be exacerbated by any component of the vaccines. * History of; or current autoimmune or other immune-mediated disease. * Administration or planned administration, of any vaccine not foreseen by the study protocol within 30 days of the first dose of vaccines up to 1 month after the last vaccine dose. * Administration of immunoglobulins and/or any blood products within the last 3 months preceding the first dose of study vaccine or planned administration during the study period. * Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection. * Any clinically relevant abnormal haematological or biochemical or urine laboratory values at screening. * Any acute or chronic, clinically significant disease, as determined by physical examination or laboratory screening tests. * Acute disease and/or fever at study entry. * Pregnant or lactating female. * Female planning to become pregnant or planning to discontinue contraceptive precautions. * History of; or current alcoholism and/or drug abuse. * Any other condition that the principal investigator judges may interfere with study findings.