OBJECTIVE: To evaluate the efficacy of prevention of contrast induced nephropathy in patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention. DESIGN: Prospective study. SETTING: Three-center study Acute kidney injury was defined as a rise in creatinine \>25% from baseline Serum creatinine will be measured at baseline and each day for the following 3 days and at 30 days. Patients will be randomised to: 1. Standard treatment 2. Standard treatment + acetylcystein for 2 days 3. Standard treatment + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours 4. Standard treatment + acetylcystein for 2 days + Sodium bicarbonate 500 ml / followed by 100 ml/h for 5 hours
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
720
Saline hydration
Acetylcystein tablets for 2 days
Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours
Sodium bicarbonate 500 ml followed by 100 ml/hour for 5 hours combined with acetylcystein tablets for 2 days
Odense University Hospital
Odense, Denmark
Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI
Rise in creatinine \>25% from baseline to day 3
Time frame: from baseline to day 3
Prevention of contrast induced nephropathy in STEMI patients treated with primary PCI
Rise in creatinine \>25% from baseline to day 30
Time frame: from baseline to day 30
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.