Ascending Multi-dose Study of REGN727(SAR236553) With and Without Concomitant Atorvastatin

Inclusion Criteria * Men and women with elevated cholesterol on stable doses of atorvastatin 10-40mg/day regimen * Body mass index between 18.0 and 35.0 kg/m2, inclusive * For women of childbearing potential, a negative serum pregnancy test at the screening visit and a negative urine pregnancy test on day -2 or day -1 * For men and women of childbearing potential, willingness to utilize adequate contraception and not become pregnant (or have their partner\[s\] become pregnant)during the full duration of the study * Willing, committed and able to return for all the clinic visits and complete all study-related procedures * Able to read, and able to sign the informed consent form Exclusion Criteria: * History of MI, ACS, Angina, Stroke, peripheral vascular disease, or cardiac revascularization * Pregnant or breast-feeding women * Blood donation of any volume within 1 month prior to administration of study drug * Congestive heart failure * Consumption of greater than 1 quart of grapefruit juice per day * Previous exposure to any therapeutic or investigational biological agent within 30 days of screening * History of alcohol or drug abuse within one year to the screening visit The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.