Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
Diltiazem 180mg for 9 months
Bisoprolol 5mg for 9 months
Candesartan 32mg for 9 months
Seoul National University Hospital
Seoul, South Korea
Wall to lumen ratio of fundus vessel
Measurement of change in the ratio of wall thickness to lumen of the fundus vessel from baseline to 9 month follow up
Time frame: baseline, 9 months
lipid parameter
Measurement of change in total cholesterol, triglyceride, LDL, small dense LDL, and HDL
Time frame: baseline, 9 months
Serum markers of inflammation
CRP
Time frame: baseline, 9 months
Change of nitrate need
Measure of change of nitrate need
Time frame: baseline, 1 months, and 3 months
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