The purpose of this study is to study the effects of Paricalcitol (Zemplar) on kidney functioning. The investigators hypothesize that the increase in serum creatinine observed in recent paricalcitol trials is a function of reduced creatinine secretion and not an actual reduction in kidney function. 16 patients will have kidney function measured via iothalamate clearance at baseline, after 7 days of paricalcitol treatment and after 7 days of being washed off the paricalcitol.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
16
2 mcg oral Paricalcitol once per day for 7 days
Roudebush VA Medical Center
Indianapolis, Indiana, United States
24-hour Urine Creatinine Excretion Rate
We expect the 24 hour urine creatinine excretion rate to show no differences between groups.
Time frame: 1 Week
Creatinine Clearance
The primary outcome variable will be creatinine clearance. Subject will be used as random variable and maximal likelihood estimation methods will be used. We expect no differences between periods.
Time frame: 1 Week
Serum Creatinine
We expect serum creatinine to confirm the results of creatinine clearance.
Time frame: 1 Week
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