The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
43
Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate.
Taabo Cité Hospital
Taabo, Côte d’Ivoire
Isotope absorption into blood stream
Time frame: Day 15
Isotope absorption into blood stream
Time frame: Day 43
Isotope incorporation into erythrocytes
Time frame: Day 15
Biochemical parameters of iron status and infection
Time frame: Day 1
Biochemical parameters of iron status and infection
Time frame: Day 15
Biochemical parameters of iron status and infection
Time frame: Day 29
Biochemical parameters of iron status and infection
Time frame: Day 43
Isotope incorporation into erythrocytes
Time frame: Day 43
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