Atopy Patch Test in Children With Food Allergy-related Gastrointestinal Symptoms

Mahidol University40 enrolled

Overview

Positive reactions in Atopy patch test in children with food allergy-related gastrointestinal symptoms

The prevalence of food allergy seems to be increasing, which might explain the increased demand for reliable evaluation of patients with suspected food-related gastrointestinal symptoms. Little is known about the diagnostic accuracy of atopy patch tests(APT) in the clinical practice. APT seems to have a better specificity than the IgE methods and seems to reflect late-phase clinical reactions.The aims of this study were to evaluate: (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test. (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Food Allergy

Interventions

Atopy patch test with food allergenDEVICE

Atopy patches used with food lyophilized allergen and commercial allergen were placed on back of subjects for 48 hrs then atopy patches were taken off. Subjects should return to evaluate the reaction one day later (72 hr after applying atopy patch test)

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who had history of suspected food allergy-related gastrointestinal symptoms eg. nausea and vomiting, diarrhea, abdominal pain or hematochezia after ingesting some food. * Age 1 month-18 yrs * Elimination diet was done at least 7 days before starting the study * Written informed consent was obtained from the parents of each child enrolled in the study Exclusion Criteria: * Who have dermographism * Who have chronic disease eg. autoimmune disease, immune deficiency, cancer or allergic disease * Pregnant women * Who have severe eczema * Who receive antihistamine, topical steroid and systemic steroid \> 20 mg/day withiin 7 days prior study

Locations (1)

Department of Pediatrics, Siriraj hospital, Mahidol University

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

Prevalence of positive reaction in APT in children with food allergy-related gastrointestinal symptoms

To evaluate (i) The prevalence of positive reaction of APTs for food allergy-related gastrointestinal diseases. (ii)Positive reaction of APT compare with skin prick test.

Time frame: 3 days

Secondary Outcomes

Comparisons atopy patch test reaction between lyophilized allergen and commercial allergen

To evaluate (iii)Positive reaction of APT using lyophilized food vs commercially available food extracts. (iv)Side effect or adverse events of APT

Time frame: 3 days

Data from ClinicalTrials.gov

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