A Study of RO5190591 (Danoprevir) in Healthy Volunteers

Inclusion Criteria: * Adult healthy volunteers, aged 18-64 years, inclusively * Weight \>/=50.0 kg * Body Mass Index (BMI) 18.0-32.0 kg/m2 * Ability and willingness to abstain from alcohol, xanthine-containing beverages or food (coffee, tea, cola, chocolate, "energy drinks") from 48 hours prior to entry in the clinical study center until discharge * Ability and willingness to abstain from grapefruit or grapefruit juice, star fruit, and Seville oranges from 7 days prior to entry in the clinical study center until discharge * Medical history without major recent or ongoing pathology Exclusion Criteria: * Pregnant or lactating women and male partners of women who are pregnant or lactating * Sustained supine systolic blood pressure \>140 or \<90 mmHG and supine diastolic blood pressure \>90 or \<50 mmHG at Screening or Day -1 * Resting heart rate \>100 or \<45 beats per minute at Screening or Day -1 * Any history of clinically significant cardiovascular or cerebrovascular disease * Positive drug test result at screening or each admission * Donation or loss of blood over 450 ml (1 pint) within 60 days prior to screening