Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram-negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant

Inclusion Criteria: * Male or female ages 18-50 years, inclusive. * The subject has provided written informed consent prior to any study procedures. * Able to attend scheduled visits and comply with trial procedures. * The subject is in good health as determined by vital signs \[heart rate \<100 beats per minutes (bpm); blood pressure: systolic greater than or equal to 90 mm Hg and less than or equal to 140 mm Hg; diastolic less than or equal to 90 mm Hg; oral temperature \<100.0 degrees Fahrenheit\], medical history to ensure stable medical condition and a physical examination based on medical history. A stable medical condition is defined as no recent change in prescription medication, dose, or frequency of medication in the last 3 months and health outcomes of the specific disease are considered to be within acceptable limits in the last 6 months. Any change that is due to change of health care provider, insurance company, etc, or is done for financial reasons, as long as in the same class of medication, will not be considered a violation of the inclusion criterion. Any change to prescription medication due to improvement of a disease outcome will not be considered a violation of the inclusion criterion. * Women of child-bearing potential or their partners must be surgically sterile or must agree to use an effective method of contraception and agree to remain on that same method through Day 120. Male subjects or their partners must be surgically sterile or must agree to use effective contraception through Day 120. (e.g. hormonal contraceptives initiated at least 30 days prior to receipt of vaccine, intrauterine devices (IUDs), diaphragm in combination with contraceptive jelly, condoms in combination with contraceptive jelly, cream, or foam; or vasectomized partner). * Have normal laboratory values for hemoglobin, white blood cells (WBC) and platelets, absolute neutrophil count (ANC), absolute lymphocyte count (ALC) obtained from the complete blood count (CBC), and serum glucose and thyroid stimulating hormone (TSH). Serum alkaline phosphatase, aspartate aminotransferase (AST), alanine transferase (ALT), blood urea nitrogen (BUN), C-reactive protein (CRP) and creatinine are not to exceed the upper limit of normal, and urinalysis must be normal on day of screening visit. * Must have a negative pregnancy test at screening (serum) and negative pregnancy test (urine) on days of vaccination, with known results prior to vaccination. * Subject agrees to avoid non-study related blood donation for 1 year following the last immunization. Exclusion Criteria: * History of allergy or severe reaction to any vaccine or vaccine components or unmethylated cytosine-guanosine motif (CPG) components. * Acute illness or fever \>/= 38 degrees Celsius/100.4 degrees Fahrenheit within a week prior to each vaccination. * Prior receipt of any Group B meningococcal outer membrane protein (OMP) vaccine. * Previous receipt of oligodeoxynucleotide adjuvant including CPG.7909. * Immunosuppression as a result of underlying illness or treatment. * Use of oral steroids, parenteral steroid or high-dose inhaled (\>800 mcg/day of beclomethasone dipropionate or equivalent) within 30 days prior to each vaccination. * Acute or chronic condition that (in the opinion of the investigator) would render vaccination unsafe or would interfere with the evaluation of responses including, but not limited to the following: cardiovascular, known chronic liver disease, significant renal disease, chronic lung diseases, unstable neurologic disorder. * Receipt of immunoglobulin or other blood product within 3 months prior to enrollment. * Current excessive use of alcohol or drug dependence (\>8 ounces of liquor or \>96 ounces of beer/day) or a history of alcohol or drug abuse in the 5 years prior to enrollment. * History of meningococcal infection. * Diagnosed autoimmune condition in either subject or immediate family member. * Under the care of a physician for a diagnosed psychiatric condition. * Women who are pregnant or breast feeding. * Women with a current or recent (i.e. within two half-lives) history of diuretic or promethazine use. * The subject is immunosuppressed as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months. * The subject has an active neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absence of therapy) or a history of any hematologic malignancy. An active neoplastic disease is defined as treatment for neoplastic disease within the past 5 years. * The subject has received an inactivated vaccine within the 2 weeks or a live vaccine within the 4 weeks prior to enrollment in this study or plans to receive another vaccine in the next 28 days. * The subject is currently participating in a study that involves an experimental agent (vaccine, drug, biologic, device, blood product, or medication) or has received an experimental agent within 1 month prior to enrollment in this study, or expects to receive another experimental agent during participation in this study. * The subject has a current or life-time diagnosis of schizophrenia, bi-polar disease, or other severe (disabling) chronic psychiatric diagnosis. * The subject has been hospitalized within the past 2 years prior to enrollment for psychiatric illness, history of suicide attempt or confinement for danger to self or others. * The subject is receiving psychiatric drugs (aripiprazole, clozapine, ziprasidone, haloperidol, molindone, loxapine, thioridazine, thiothixene, pimozide, fluphenazine, risperidone, mesoridazine, quetiapine, trifluoperazine, trifluopromazine, chlorprothixene, chlorpromazine, perphenazine, olanzapine, carbamazepine, divalproex sodium, lithium carbonate or lithium citrate). Subjects who are receiving a single antidepressant drug, are not diagnosed with depression and are stable for at least 3 months prior to enrollment without decompensating are allowed enrollment into the study. * The subject has a known human immunodeficiency virus, hepatitis B, or hepatitis C infection. * The subject has an electrocardiogram (EKG) showing pathologic Q waves and significant ST-T wave changes; left ventricular hypertrophy; any nonsinus rhythm excluding isolated premature atrial contractions; right or left bundle branch block; or advanced (secondary or tertiary) A-V heart block. * The subject has a history of working in an infectious disease laboratory. * Any condition that would, in the opinion of the investigator, place the subject at an unacceptable risk of injury or render them unable to comply with the protocol.