Characterization of the Kinetics of Renal Glucose Reabsorption in Response to Dapagliflozin in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus (T2DM)

Inclusion criteria for T2DM * Diagnosis of T2DM * Must be on one of the following therapies: diet therapy alone, diet plus a sulfonylurea, diet plus metformin, or diet plus sulfonylurea plus metformin * Subjects taking metformin, and/or sulfonylurea must be on a stable dose for at least 2 months prior to study drug administration * Must have a fasting plasma glucose concentration ≤ 200 mg/dl, and HbA1C ≤ 10% Inclusion criteria for healthy subjects: * Healthy subjects (as determined by no clinically significant deviation from normal in medical history, physical examination, ECGs, and clinical laboratory determinations) Inclusion criteria for all subjects: * Subjects with (eGFR ≥ 60 and ≤ 160 mL/min/1.73m² and urinary albumin excretion \< 300 mg/g creatinine) * Body Mass Index (BMI) of 18 to 38 kg/m² * Men and women, ages 18 to 65 years, inclusive Exclusion criteria for all subjects: * Subjects with Type 1 Diabetes or uncontrolled Type 2 Diabetes Mellitus * Subjects with T2DM with fasting plasma glucose \> 200 mg/dL, healthy subjects with fasting plasma glucose \> 105 mg/dL * Subjects with T2DM with HbA1C \> 10.0%, healthy subjects with HbA1C \> 6.8%