High blood pressure is related to increased risk of cardiovascular disease and death, and accounts for approximately 8 mill deaths worldwide each year. Blood pressure exhibits a seasonal variation with a tendency to increase during winter months. Vitamin D deficiency is more common during months where UVB radiation from the sun is absent, and vitamin D has been associated with high blood pressure. This study will evaluate the effect of vitamin D replacement during winter months on blood pressure and vasoactive hormones in patients with high blood pressure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
136
3 tablets of 1000 IU daily for 20 weeks
3 placebo tablets daily for 20 weeks
Department of Medical Research
Holstebro, Holstebro, Denmark
24-hour systolic blood pressure
Time frame: 20 weeks
Plasma renin concentration
Time frame: 20 weeks
Plasma concentration of angiotensin II
Time frame: 20 weeks
Plasma concentration of aldosterone
Time frame: 20 weeks
Plasma concentration of c-reactive protein
Time frame: 20 weeks
Urine albumin creatinine ratio
Time frame: 20 weeks
Urine calcium creatinine ratio
Time frame: 20 weeks
Plasma concentration of 25-hydroxycholecalciferol
Time frame: 5 weeks
Serum concentration of FGF-23
Time frame: 20 weeks
Augmentation index and central blood pressure
Time frame: 20 weeks
Pulse wave velocity
Time frame: 20 weeks
Heart rate variability
Time frame: 20 weeks
Plasma concentration of ionized calcium
Time frame: 5 weeks
Plasma concentration of phosphate
Time frame: 5 weeks
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