Endoscopic Ultrasound-guided Celiac Plexus Neurolysis in the Management of Pain in Abdominal Non-pancreatic Malignancies

Inclusion Criteria: * Diagnosis of an unresectable, non-pancreatic malignancy, including gastric, small intestinal, or proximal colonic malignancies, as well as malignancies of the liver and bile ducts (based on above celiac plexus innervations) * Pain directly related to the primary malignant process, as determined by the referring oncologist * Pain determined to be refractory to standard medical therapy, or when the medical therapy is ineffective due to certain limitations (such as severe constipation), as determined by the referring oncologist * Willingness to undergo EUS-guided CPN * Age \> 18 years * ECOG performance status of grades 0-3 \[7\] * The patient will need to sign informed consent prior to inclusion in this study Exclusion Criteria: * Unable or unwilling to undergo an EUS-guided CPN * Contraindication to anesthesia, as determine during the preoperative clearance process * Refractory coagulopathy (INR \> 1.5) or thrombocytopenia (platelet count \< 50,000), or aspirin and/or clopidogrel use within 7 days of procedure * Current pregnancy * Prior celiac plexus block/neurolysis * Allergy to local anesthetics * ECOG performance status of grade 4 or higher