A Study in Critically Ill Patients Investigating Tolerability and Efficacy of Low-volume Pharmaconutrition (Intestamin)

Inclusion Criteria: * sepsis or SIRS (APACHE score 10-30), * no severe gastrointestinal tract or metabolic diseases, * enteral feeding within 48 h of admission, * age 18-75 years, * written consent by patient or next of kin. - Exclusion Criteria: * participation in a drug trial within the last 4 weeks before inclusion in this study, * previous participation in this study, * expected patient survival of less than 6 days, * pregnancy or lactation, * patients with unstable vital signs that would probably cause incidents that would make participation impossible or would lead to discontinuation, * severe liver disease with cytolysis (ASAT \>10 N) or impaired detoxification (ammonia \>50 mmol/L, bilirubin \> 50 μmol/L), * gastrointestinal surgery in the last 4 weeks, * severe enteritis/colitis, * short intestine syndrome, * gastrointestinal bleeding that requires intervention, * patients who could not be enterally fed