This study aims to prospectively estimate the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) at St. Jude Children's Research Hospital (SJCRH) using the FilmArrayTM System, a novel highly sensitive and rapid assay for RV detection. An aliquot from the leftover sample remaining after clinical diagnostic testing will be used for FilmArrayTM analysis. Patients will be accrued on the study over a one year period.
The Primary Objective of the study is: * Prospectively estimate the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) at St. Jude Children's Research Hospital(SJCRH). The Secondary Objectives of the study are: * Study the association between RV infections and clinical variables. * Prospectively estimate the duration of RV infections in symptomatic children at SJCRH. * Compare the sensitivity and specificity of the current molecular method of analysis of respiratory viruses with the FilmArrayTM method.
Study Type
OBSERVATIONAL
Enrollment
350
St . Jude Children's Research Hospital
Memphis, Tennessee, United States
This study measures the incidence of Respiratory virus (RV) infections in children with symptoms of an upper respiratory tract infection (URTI) or lower respiratory tract infection (LRTI) using the FilmArray System
This study uses FilmArrayTM System, a novel highly sensitive and rapid assay for respiratory virus infection. An aliquot from the leftover sample remaining after clinical diagnostic testing will be used for FilmArrayTM analysis
Time frame: 1 year
Time of first detection of the virus as related to day of transplant, Time of first detection of the virus as related to day of chemotherapy and duration of viral shedding from the time of first detection will all be measured.
Different variables will be collected to find the association between Respiratory virus and clinical variables
Time frame: 1 year
This study prospectively estimates and measures the duration of Respiratory Virus infections in symptomatic children by studying the epidemiology and natural history of infections with these viruses .
These viruses have been known to cause interstitial lung disease, will help clarify the etiology of "idiopathic pneumonia" post chemotherapy .
Time frame: 1 year
This study analyses respiratory viruses using Filmarray TM method
Time frame: 1 year
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