Postoperative infectious morbidity remain the most frequent, threatening and costly event after major surgery. Maintenance of postoperative euglycemia might be a key factor to prevent such complications and given the preliminary data on the positive effect of carbohydrate load on glucose metabolism it might also be valuable in improving outcome. If this treatment will be proved effective on relevant outcome measure such as rate of infections, it might be used routinely and extensively because preoperative carbohydrates administration is cheap, simple and applicable by everyone in any surgical ward. The aim of the trial is to evaluate if the normalization of blood glucose by means of preoperative oral administration of maltodextrine, in patients candidate to elective major surgery, may be effective in improve surgical morbidity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
880
a carbohydrate beverage (total carbohydrates equal to 12.6g/100 mL: 2.1 g monosaccharide, 10.0 g maltodextrine; 240 mOsm/L) in dose of 800 mL
The control group will receive plain water with the same volume and timing of treatment.
San gerardo hospital
Monza, Italy
rate of postoperative complications
Time frame: 30 days
rate of patients needing insulin treatment
Time frame: 4 days
rate of total complications
Time frame: 30 day after surgery
rate of patients needing antibiotic therapy
Time frame: 30 days after surgery
rate of reopaeration
Time frame: 15 days
rate of patients needing intensive care treatment
Time frame: 15 days
length of hospital stay
Time frame: 15 days
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