Obesity is increasing in France, resulting in an increased demand for bariatric surgery. However obesity also alters physiopathological pathways and the pharmacokinetics of anesthestic agents. The investigators objective is to compare, among morbidly obese patients, the immediate and intermediary emergence kinetics after balanced anesthesia using remifentanil associated either with desflurane (reference arm) or with xenon (experimental arm).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
192
Patients undergo anesthesia using remifentanil associated with desflurane
Patients undergo anesthesia using remifentanil associated with xenon
CHU de Clermont Ferrand - Hôpital Estaing
Clermont-Ferrand, France
CHRU de Lille - Hôpital Claude Huriez
Lille, France
CHU de Montpellier - Hôpital Saint-Eloi
Montpellier, France
CHU de Nice - Hôpitaux L'Archet 1 et 2
Nice, France
30 min DSST ratio
(the number of correct responses to a Digit Symbol Substitution Test \[DSST\] 30 minutes after surgery) / (the number of correct responses to a Digit Symbol Substitution Test the night before the surgery)
Time frame: 30 minutes post-op
60 min DSST test
(the number of correct responses to a Digit Symbol Substitution Test 60 minutes after surgery) / (the number of correct responses to a Digit Symbol Substitution Test the night before the surgery)
Time frame: 60 minutes post-op
90 min DSST test
(the number of correct responses to a Digit Symbol Substitution Test 90 minutes after surgery) / (the number of correct responses to a Digit Symbol Substitution Test the night before the surgery)
Time frame: 90 min post-op
Time to Aldrete score of 10
Aldrete JA. The post-anesthesia recovery score revisited. J. Clin. Anesth. 1995.
Time frame: Immediate post-op; this outcome measures the minutes of emergence (from anesthesia) time necessary to attain an Aldrete score of 10
Quality of recovery score
The score on the Quality of Recovery Scale: Myles PS, Weitkamp B, Jones K et al. Validity and reliability of a postoperative quality of recovery score: the QoR-40. Br. J. Anaesth., 2000; 84: 11-15.
Time frame: Day 1 post-op
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CHU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, France
CHU de Poitiers
Poitiers, France