Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)

Johann Wolfgang Goethe University Hospital250 enrolled

Overview

In this study patients with 1. chronicle liver diseases * primary biliary cirrhosis * primary sclerosing cholangitis * alcoholic liver cirrhosis * hepatitis b or C * Wilson's disease * cryptogenic cirrhosis 2. Septic Inflammatory Response Syndrome (SIRS) * sepsis * septic shock 3. patients after lysis should be included Blood samples will be gathered from the patients to measure fibrinogen with 5 different methods. The methods are: * Clauss fibrinogen * PT-Derived fibrinogen * immunoturbidimetric method * heat-precipitated fibrinogen * Schulz fibrinogen The result of these tests will be correlated with laboratory values which are gathered in routine and the clinical outcomes.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

SIRS Sepsis Liver Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * SIRS * sepsis * septic shock * chronicle liver disease (MELD-Score \>10) * patient after lysis * patient agrees Exclusion Criteria: * no agreement

Locations (1)

Outcomes

Primary Outcomes

Fibrinogen levels from 5 test methods

* Clauss fibrinogen * PT-Derived fibrinogen * immunoturbidimetric method * heat-precipitated fibrinogen * Schulz fibrinogen

Secondary Outcomes

Number of bleedings

Number of administered fresh frozen plasma

Number of administered erythrocyte concentrates

Number of administered thrombocyte concentrates

mortality