Both vitamin D deficiency and type II DM/prediabetes are highly prevalent. Vitamin D status has been negatively associated with the presence of type II DM and glycemic control. A cause-effect relationship between vitamin D deficiency and the development of type II DM has not been established. The investigators plan to conduct a 2 year, double blind, randomized, placebo controlled trial on the effect of vitamin D3 supplement on the incidence of type II DM in high risk individuals.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
25
Vitamin D3 5000 IU orally, daily for 2 years
Placebo orally, daily for 2 years
King Faisal Specialist Hospital & Research Center
Riyadh, Saudi Arabia
The incidence of DM
Development of DM diagnosed by glucose levels, fasting and/or 2-hour post 75 mg glucose challenge.
Time frame: 2 years
slope of fasting glucose level
Time frame: 2 years
slope of 2-hour post challenge glucose level
Time frame: 2 years
area under the curve of BP
Time frame: 2 years
area under the curve of weight
Time frame: 2 years
area under the curve of 25 OH vitamin D level
Time frame: 2 years
fasting insulin to glucose ratio
Time frame: 2 years
incidence of hypercalcemia
Time frame: 2 years
incidence of hypercalciuria
Time frame: 2 years
time to develop DM
Development of DM diagnosed by glucose levels, fasting and/or 2-hour post 75 mg glucose challenge.
Time frame: 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.