Vitamin D deficiency is common world wide. 25 OH vitamin D level is the best indicator of vitamin D status. Vitamin D supplements are available as vitamin D2 or D3, in small daily or large weekly/monthly doses. Controversy continues on the relative potency of vitamin D2 compared to D3 and of daily compared to weekly or monthly doses, in increasing/maintaining total 25 OH vitamin D level. The investigators plan to conduct a controlled trial to compare the effect of various vitamin D supplements on 25 OH vitamin D levels in healthy adults with starting 25 OH vitamin D level between 20 to 50 nmol/L.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
279
ergocalciferol 2000 IU orally, daily
ergocalciferol 25000 IU oraly every 2 weeks
ergocalciferol 50000 IU orally every 4 weeks
ergocalciferol 1000 IU and cholecalciferol 1000 IU orally every day
cholecalciferol 2000 IU orally everyday
Cholecalciferol 25000 IU orally every 2 weeks
Cholecalciferol 50000 orally every 4 weeks
placebo orally everyday
King Faisal Specialist Hospital & research Center
Riyadh, Saudi Arabia
area under the curve of 25 OH vitamin D level
area under the curve of total 25 OH vitamin D level from day 1 to 140
Time frame: 140 days
Cmax of 25 OH vitamin D
Cmax of total 25 OH vitamin D over the treatment period of 140 days
Time frame: 140 days
Tmax of 25 OH vitamin D level
Tmax of total 25 OH vitamin D over the treatment period of 140 days
Time frame: 140 days
area under the curve of vitamin D level
area under the curve of total vitamin D level over 140 days
Time frame: 140 days
incidence of hypercalcemia
Time frame: 140 days
incidence of hypercalciuria
Time frame: 140 days
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