Does corticosteroid (dexamethasone) have an effect on the postoperative period after laparoscopic hernia repair, when it comes to pain, postoperative nausea and vomiting and convalescence. This randomized, double-blinded study compares dexamethasone versus placebo. The patients are recommended one day of convalescence. The medicine or placebo is given before operation. The patients fill out questionnaire before operation and three hours after operation and in the following three days. The patients also register when they return to normal activities and work.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
80
single use of dexamethasone IV 8 mg/2 ml
2 ml IV
University Hospital Koege
Koege, Denmark
pain during coughing
Assessed with visual analog scale (VAS 0-100 mm)
Time frame: day 1
pain during coughing
Assessed with VAS
Time frame: 4 days
pain at rest
Assessed with VAS
Time frame: 4 days
convalescence
Registration of number of days after operation before returning to work and recreational activities.
Time frame: 1 month
pain at rest
Assessed with verbal rating scale (VRS:no pain, mild pain, severe pain, worst thinkable pain)
Time frame: 4 days
nausea
Assessed with verbal rating scale (VRS: no nausea, mild nausea, severe nausea, worst thinkable nausea)
Time frame: 2 days
vomiting
yes/no question. If yes, how many times have you been vomiting?
Time frame: 2 days
discomfort
Assessed with visual analog scale (VAS, 0-100 mm)
Time frame: 4 days
fatigue
Assessed with numeric rating scale (NRS, 1-10)
Time frame: 4 days
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