A neutrophil elastase inhibitor may have effect on suppression of the lung injury after thoransthoracic esophagectomy. The investigators hypothesized that postoperative complication, particularly respiratory complication may be reduced by neutrophil elastase inhibitor after esophagectomy.
The aim of this study was to clarify the usefulness of perioperative administration of sivelestat sodium hydrate, a selective inhibitor of neutrophil elastase in the pulmonary function, systemic inflammatory response, and the postoperative clinical course following video-assisted thoracoscopic esohpagectomy for esophageal cancer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
31
saline or sivelestat sodium hydrate intravenously for 7 days starting the beginning of surgery
Chikara Kunisaki
Yokohama, Kanagawa, Japan
Pulmonary function
the arterial oxygen pressure
Time frame: 9 days
Pulmonary function
fraction of inspired oxygen ratio (PF ratio)
Time frame: 9 days
Pulmonary function
the duration of mechanical ventilation
Time frame: 9 days
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