Indapamide Versus Hydrochlorothiazide in Elderly Hypertensive Patients With Renal Insufficiency

Inclusion Criteria: * Creatinine clearance 30 to 90 mL/min/1.73 m2, with variations of less than 20 percent in the 2 weeks before the screening evaluation. * Diagnosed hypertension according to guidelines or having taken anti-hypertension drugs. * Aged between 65 and 85 years. * Willingness to provide written, informed consent. * Ability to adhere to study protocol. Exclusion Criteria: * Secondary hypertension. * Diabetes mellitus. * Atrial flutter/atrial fibrillation. * Symptoms of congestive heart failure (NYHA III-IV) or there is evidence that left ventricular EF \< 40%. * Recent (\< 6 months) myocardial infarction or cerebrovascular ischemic symptoms. * Recent (\< 3 months) or planned coronary revascularization: PCI (percutaneous coronary intervention)/CABG (coronary artery by-pass graft). * Severe valvular heart disease. * History of hypersensitivity to indapamide, thiazides or to any of the components of the products. * Any current condition or other disease known to interfere significantly with the absorption, distribution, metabolism or excretion of study drugs. * Participation to another investigational study in the last 3 months.