This is a Phase I, single-center, three-arm, randomized, double-blind, active- and placebo-controlled study to investigate the effect of GDC-0449 on the QT/QTc interval in healthy female subjects of non-childbearing potential.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
61
The QTcF (QT interval corrected by Fridericia's correction method)
Time frame: Throughout study or until early discontinuation
Change in ECG from baseline
Time frame: Throughout study or until early discontinuation
Pharmacokinetic parameters of GDC-0449
Time frame: Throughout study or until early discontinuation
Incidence, nature and severity of adverse events
Time frame: Throughout study or until early discontinuation
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