Liposuction is the most popular aesthetic surgery in Brasil and worldwide. Evidence showing that adipose tissue is a metabolically active tissue led to the suggestion that liposuction could be a viable method for the improvement of metabolic profile through the immediate loss of adipose tissue. Studies about the effects of liposuction on metabolic profile are conflicting. A few studies report the improvement of insulin sensitivity, inflammatory markers and lipid profile, others observe no changes and a few report the worsening of metabolic profile. In addition, animal studies show a compensatory growth of intact adipose tissue in response to lipectomy. Physical exercise improves insulin sensitivity, lipid profile, inflammatory balance, adipose tissue distribution and increases or preserves free fat mass. Therefore, liposuction and physical exercise seem to act on similar tissues of the body. To the investigators knowledge, there are no studies about the associated effects of liposuction and exercise in humans. However, one can suggest that exercise training associated with liposuction could: \[1\] attenuate or block the possible fat recovery or compensatory growth; \[2\] block or reverse the possible harmful effects of liposuction; or \[3\] exert an additive or synergistic effect to the possible beneficial effects induced by liposuction on metabolic and hormonal profile and inflammatory balance.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
combined resistance and aerobic training
Escola de Educação Física e Esporte da Universidade de São Paulo
São Paulo, São Paulo, Brazil
Body composition
Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas.
Time frame: 2 months post-intervention
Body composition
Body composition will be assessed by hydrostatic weighing in order to measure fat and lean mass and by computer tomography, in order to measure abdominal total, subcutaneous and visceral fat areas and femoral and pelvic subcutaneous fat areas.
Time frame: 6 months post-intervention
Insulin Sensitivity
Insulin sensitivity will be assessed by an oral glucose tolerance test
Time frame: 2 months post-intervention
Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels
Time frame: 2 months post-intervention
Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels
Time frame: 2 months post-intervention
Insulin Sensitivity
Insulin sensitivity will be assessed by an oral glucose tolerance test
Time frame: 6 months post-intervention
Total cholesterol, LDL-c, HDL-c, VLDL-c and triacylglycerol plasma levels
Time frame: 6 months post-intervention
Cytokine plasma levels - IL-6, TNF-alpha, IL-10, leptin and adiponectin levels
Time frame: 6 months post-intervention
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