New Castle Disease Virus (NDV) in Glioblastoma Multiforme (GBM), Sarcoma and Neuroblastoma

Inclusion Criteria: * Evidence of progressive disease in the above categories evaluated by standard tumor staging. * Histologically confirmed diagnosis. * Failure of conventional anti- cancer modalities.despite optimal application of all relevant available anti- cancer modalities. * Age between 3 and 75 years old. * Liver function tests less than twice the normal, renal function no more than 20% reduction and white cell and platelets count no more than 30% reduction. * Karnofsky performance status of 50% or greater * A written informed consent understood and signed by the patient and by a spouse, parent or guardian. In patients with GBM two signs will be required due to possible alterations of psych and understanding. Exclusion Criteria: * Not fulfilling any of the above criteria * Moribund patients or patients with life- expectancy \< 3 months * Karnofksy performance status \< 50% * Pregnant or lactating women * Active local or systemic infections requiring treatment * Patients receiving other investigational agents * History of allergy to egg ova-albumin. * Co-morbidity or life- threatening clinical condition other than the basic cancer