The aim of the study is to compare three different regimens for volume replacement during cardiac surgery, e.g. Albumin 5%, Hydroxyethylstarch 130/0.4 (HES) and Ringer-Lactate (RL). Main Outcome parameters: chest tube drainage and coagulation parameters. The investigators hypothesis is that HES is as safe as Albumin, however less expensive. Whether RL is an even less expensive and as safe alternative has to be shown.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
240
Hydroxyethylstarch up to 50mL/kg/24 hrs
Humanalbumin 5% up to 50 mL/kg/24 hours
up 10 50mL/kg/24 hours
Vienna General Hospital
Vienna, State of Vienna, Austria
chest tube drainage
Time frame: 24 hours
Hemoglobin concentration
Time frame: induction of anesthesia = baseline
Hematocrit value
Time frame: induction of anesthesia = baseline
platelet count
Time frame: induction of anesthesia = baseline
activated clotting time
Time frame: induction of anesthesia = baseline
Modified thromboelastometry coagulation analysis (ROTEM, Pentapharm, Munich, Germany)
using 3 activators: intrinsic ROTEM (InTEM, extrinsic ROTEM (ExTEM), finbrinogen ROTEM (FibTEM)
Time frame: induction of anethesia = baseline
Hemoglobin concentration
Time frame: average 1 hour on cardiopulmonary bypass
Hematocrit value
Time frame: average 1 hour on cardiopulmonary bypass
Modified thromboelastometry coagulation analysis (ROTEM, Pentapharm, Munich, Germany)
using 3 activators: intrinsic ROTEM (InTEM, extrinsic ROTEM (ExTEM), finbrinogen ROTEM (FibTEM)
Time frame: average 1 hour on cardiopulmonary bypass
activated clotting time
Time frame: average 1 hour on cardiopulmonary bypass
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Hemoglobin concentration
Time frame: 30 minutes after arrival ICU
Hematocrit value
Time frame: 30 minutes after arrival ICU
platelet count
Time frame: 30 minutes after arrival ICU
activated clotting time
Time frame: 30 minutes after arrival ICU
Modified thromboelastometry coagulation analysis (ROTEM, Pentapharm, Munich, Germany)
using 3 activators: intrinsic ROTEM (InTEM, extrinsic ROTEM (ExTEM), finbrinogen ROTEM (FibTEM)
Time frame: 30 minutes after arrival ICU
Hemoglobin concentration
Time frame: 24 hours after surgery
Hematocrit value
Time frame: 24 hours after surgery
platelet count
Time frame: 24 hrs after surgery
Modified thromboelastometry coagulation analysis (ROTEM, Pentapharm, Munich, Germany)
using 3 activators: intrinsic ROTEM (InTEM, extrinsic ROTEM (ExTEM), finbrinogen ROTEM (FibTEM)
Time frame: 24 hrs after surgery