A Study to Evaluate the Safety and Effectiveness of EVICEL as an Adjunct to Sutured Dural Repair

Inclusion Criteria: * Patient undergoing elective craniotomy/craniectomy * Age greater than or equal to 18 years * Patients who are able and willing to comply with the procedures required by the protocol. * Signed and dated written informed consent from the subject or from his/her legal representative prior to any study-related procedures. Exclusion Criteria: * Chemotherapy or radiation therapy within 7 days following surgery. * Conditions compromising the immune system. * Known hypersensitivity to the components (human fibrinogen, arginine hydrochloride, glycine, sodium chloride, sodium citrate, calcium chloride, human thrombin, human albumin, mannitol and sodium acetate) of the investigational product. * Female subjects of childbearing potential with a positive pregnancy test prior to surgery. * Female subjects who are breastfeeding or intend to become pregnant during the clinical study period. * Participation in another clinical trial with exposure to another investigational drug or device within 30 days prior to enrollment. * Major intraoperative findings or complications identified by the surgeon that may preclude conduct of the planned surgical procedure.