58 patients undergoing surgery of the large bowel are divided into two groups. The control group will receive standard care. The intervention group will receive standard care plus optimization of the blood circulation based on in- or decrease of the output of the heart. Between group differences are measured primarily by markers of intestinal damage in plasma and urine. Also CO2 pressure in the stomach lumen is measured (reflecting blood supply to the gut). The investigators hypothesize that the intervention group will have less intestinal damage, improved blood supply to the bowel and improved recovery of the operation compared to the control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
58
Fluid administration and optimization based on cardiac output findings during surgery and during the first 8 hours of the postoperative phase.
Fluid regimen based on expertise anaesthesist
University Hospital Maastricht
Maastricht, Limburg, Netherlands
Peak Value of I-FABP
Intestinal-Fatty Acid Binding Protein (a marker of intestinal damage) is measured in plasma. The primary outcome measure is the difference in peak values of I-FABP between the control group and the intervention group.
Time frame: 1 hour postoperatively
Average Intraoperative CO2 Gap
The CO2 gap (difference arterial pCO2 and pCO2 of the stomach lumen) reflects global intestinal perfusion status and is measured every 15 minutes intraoperatively and every 60 minutes during the first 8 hours postoperatively. Intraoperative measurements were averaged per individual patient, producing the average intraoperative CO2 gap.
Time frame: Average intraoperative CO2 gap
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.