The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

Yonsei University46 enrolled

Overview

Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Healthy Subjects

Interventions

NicardipineDRUG

remifentanilDRUG

0.1-0.5 ugkg/min during hypotensive anesthesia

Eligibility

Sex: ALLMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy adult patients undergoing hypotensive anesthesia Exclusion Criteria: * patients with any co-morbidity

Outcomes

Primary Outcomes

Creatinine Clearance

Hypotensive anesthesia means that we maintain the mean blood pressure between 55 \& 65 mmHg during surgery to decrease the blood loss. The specific time point is exactly 2hr after we star to lower the blood pressure.

Time frame: 2hr after the start of hypotensive anesthesia

Data from ClinicalTrials.gov

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