Proteomic Analysis of Human Hepatocellular Carcinoma

Far Eastern Memorial Hospital5 enrolled

Overview

This is a pilot study to evaluate the difference between the protein expression between hepatocellular carcinoma and tumor with vessel invasion in Asian patients with hepatocellular carcinoma.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Carcinoma, Hepatocellular

Interventions

OperationPROCEDURE

Operation for clinically evaluated resectable hepatocelluar carcinoma. Compare the different expression of protein between tumor, non-tumor and tumor with vascular invasion part.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: Arm A: Hepatocellular carcinoma with vessel invasion: * hepatocellular carcionoma, pathologic diagnosed. * image documented vessel invasion, including portal vein thrombosis * eligible for surgical intervension. Arm B: hepatocellular carcinoma without vessel invasion: * hepatocellular carcinoma, pathologic diagnosed or clinical diagnosed according to EASL criteria. * no vessel invasion on image. Arm C: Healthy hepatitis carrier: * patients age \>18 years old with hepatitis B or C * normal liver function.

Locations (1)

Far Eastern Memorial Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

Recurrence

Evidence of clinically definite vascular invasion of hepatocellular carcinoma. Confirmed by operation. Compare the proteomic expression of tumor, non-tumor ans tumor tissue in vascular part.

Time frame: one year

Data from ClinicalTrials.gov

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