Study hypothesis is that patients on antipsychotics medication treated with metformin will show loss in weight and improved measures of glucose metabolism.
Patients who had gained more than 10 lbs of weight in the last 3 months or had BMI of 35 or greater were treated with metformin up to 2500 mg/day in an open label study of up to 3 months time. Changes in weight and glucose measures were recorded.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
metformin 500- 2500 mg/day. Patient received variable doses of metformin starting at 500 mg/day and increasing up to maximum of 2500 mg/day over 3-4 weeks. Dose was titrated on tolerability and side effects, especially development of hypoglycemia. This explains why different patients received different maximum doses.
Manhatan Psychiatric Center
New York, New York, United States
Weight (wt) in Pounds (Lbs)..
Patients weight in pounds
Time frame: baseline, 4 weeks, 8 weeks, 12 weeks
Glucose Levels
Fasting glucose
Time frame: baseline, 4 weeks, 8 weeks, 12 weeks
Insulin Level
fasting serum insulin uIU/ml.
Time frame: baseline, 4 weks, 8 weeks, 12 weeks
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