Genetic Analysis of Familial Cases of Premature Ovarian Failure

Inclusion Criteria: Patients of familial cases of POF : * Female subjects between 16 and 40 years or women older than 40 years with a cessation of ovarian function before the age of 40 years with increased levels of FSH * Primary or secondary amenorrhea for more than three months with LH and FSH\> 30mUI/ml * No cases of fragile X syndrome in the family or blepharophimosis syndrome * At least two cases in the family * Origin Caucasian * Patient signing the consent form for at least the blood sample * Patient with Social Security Population Index related topics : * The presence of cycles until the age of 40 years with proven fertility, at least one child * Amenorrhea and FSH\> 30mUI/ml according to the criteria of the index subject * Men of the family of index case Population control : * Women of Caucasian origin * Women who had regular cycles until at least age 40 and at least one child * Lack of land autoimmune (no history of thyroid disease or diabetes type 1) * Woman signing the consent form for at least the blood sample Exclusion Criteria: * Blood donation of more than 450ml in the previous three months. * Subject with an abnormal karyotype in favor of Turner syndrome or having a premutation of the FMR1 gene or a syndromic form * Subject exclusion period in another study without direct individual benefit * Subject refusing to sign the consent form