Multicenter Placebo Controlled Study to Assess the Effect of Rasagiline on Sleep-wake Disturbances in Patients With Parkinson's Disease

Inclusion criteria: 1. Probable diagnosis of Parkinson's disease according to the modified UK Parkinson's Disease Society Brain Bank criteria 2. Hoehn and Yahr up to stage 3 in the off-state 3. Age = 40 years 4. On the basis of a physical examination and medical history, the patient is in the investigator's opinion otherwise healthy 5. Parkinson's Disease Sleep Scale (PDSS) score = 90. 6. Patients with stable dosage of hypnotics / sedative /neuropsychiatric treatment including antiParkinsonian treatment in the last 4 weeks before screening evaluation and with no change foreseen during the study period. Dose adjustments can be made, but no change or discontinuation of drugs. 7. Subjects must understand questionnaires in German, French or Italian 8. Provided signed informed consent 9. Females of childbearing potential must agree to utilize highly effective contraceptive methods of birth control. 10. Females of child bearing potential must have a negative pregnancy test. Exclusion criteria: 1. Diagnosis unclear or suspicion of another than Parkinson's disease 2. Patients with cognitive deficit (MMSE \< 26) 3. Patients who have undergone surgery for the treatment of PD 4. Patients with non-response to adequate antiParkinsonian treatment 5. History of moderate to severe hepatic insufficiency. 6. Clinically relevant or unstable vascular disease 7. History of drug or alcohol abuse (within the past 10 years) 8. Patients with a history of psychotic disorders 9. Patients with treatment resistant/recurrent major depression (HADS =19) 10. Patients with unstable dosage of antiParkinsonian or neuropsychiatric treatment in the last 4 weeks before screening evaluation. 11. Concomitant use of fluoxetine, fluvoxamine, pethidine or monoamine oxidase inhibitors (MAOI) during the course of the study and within 3 months prior to screening evaluation. Patient may be rescreened 3 months after discontinuation of the above mentioned drugs. 12. Concomitant use of dextromethorphan, ephedrine or pseudoephedrine during the course of the study 13. Women who are pregnant or lactating 14. Participation in another study during or up to 30 days prior to participation in this study