Study of Everolimus in the Treatment of Advanced Malignancies in Patients With Peutz-Jeghers Syndrome

Tow cohorts of PJS patients will be included. Cohort 1: Advanced malignancy Cohort 2: High risk polyps General inclusion criteria: 1. Known Peutz-Jeghers disease (with LKB1 mutation) 2. No concurrent systemic anti cancer treatment 3. No prior treatment with m-TOR inhibitor 4. Prior malignancies or concurrent second malignancies are allowed 5. Prior systemic therapy is permitted with a washout time of at least 4 weeks 6. ECOG/ WHO performance 0-2 7. Age \> 18 years 8. Adequate renal function (defined as creatinine \< 150 μmol/L) 9. Adequate liver function (bilirubin \< 1.5 times upper limit of normal, ALAT or ASAT \< 5.0 times upper limit of normal in case of liver metastases and \< 2.5 the upper limit of normal in absence of liver metastases 10. Adequate bone marrow function (WBC \> 3.0 x 10 9/L, platelets \> 100 x 10 9/L) 11. Absence of any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule; those conditions should be discussed with the patient before registration in the trial. 12. No pregnancy or lactating and ifof childbearing potential patients must agree to use a reliable contraceptive method throughout the study 13. No serious concomitant systemic disorder that would compromise the safety of the patient,at the discretion of the investigator 14. Signed informed consent according to ICH/GCP. 15. No uncontrolled symptomatic hyperglycaemia Specific inclusion criteria for cohort 1: 1. Cytological or histological confirmed carcinoma 2. Metastatic or non-resectable disease 3. Patients with clinically and/or radiographically documented measurable lesion according to RECIST criteria: 1. X-ray, physical exam \> 20 mm 2. Spiral CT scan \> 10 mm 3. Non-spiral CT scan \> 20 mm Specific inclusion criteria for cohort 2: 1. Known high risk polyps (definition see page 19) 2. Ability to undergo endoscopies Specific Exclusion criteria: Symptomatic PJ-polyps, defined as polyps likely to be responsible/causal for the abdominal symptoms the patient presents with.