MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation

Inclusion Criteria: * Females aged 40-62 years. * Menopausal, including: * Women who have had a bi-lateral oophorectomy; * Women with a uterus who have skipped 2 or more menstrual cycles with an amenorrhea interval of 60 or more days in the past 12 months; * Women without a uterus and who still have one or both ovaries, with FSH level greater than 20 mIU/mL and estradiol less than or equal to 50 pg/mL; * Women who are using the Mirena IUD or who have had an endometrial ablation and who still have one or both ovaries, with FSH level greater than 20 mIU/mL and estradiol less than or equal to 50 pg/mL. * Having bothersome hot flashes and/or night sweats. * In general good health as determined by medical history, blood pressure, and heart rate: * Absence of uncontrolled hypertension greater than 160/100; * Resting heart rate less than 110 beats per minute;. * No history of myocardial infarction, angina, or cerebrovascular events;. * No history of liver, renal disease, or uncontrolled seizure disorder. * Absence of uncontrolled metabolic disease (such as diabetes) and absence of current infectious disease (such as acute symptoms of mononucleosis) that would put staff and other participants at risk. * Signed informed consent. Exclusion Criteria: * Use of hormone therapy or hormonal contraceptives (with the exception of the Mirena IUD) during the 2 months before enrollment. Vaginal postmenopausal estrogens allowed, with the exception of vaginal creams used more than 3 times a week. * Use of any other therapy that is taken specifically for hot flashes, including prescription, over-the-counter, or herbal therapies, in the past month. * Any current severe or unstable medical illness. * Body mass index (BMI) of 37 or higher, based on measured height and weight. * Severe uncorrected hearing or vision problems. * Current, regular use of anti-coagulants 3 or more times per week, e.g. Coumadin, Heparin, Clopidogrel, aspirin at full dose (due to possible omega-3 supplement interaction). * Drug or alcohol abuse in the past 1 year. * Major severe depressive episode in the past 3 months. * Diagnosis of psychosis or psychotic disorder. * Pregnancy, intending pregnancy, or breastfeeding. * Current participation in another drug trial or intervention study. * Inability or unwillingness to complete the study procedures or interventions. * Physical limitations that limit the ability to participate in yoga or exercise, for example: * Limited mobility (paralyzed, cannot walk 2 blocks); * Back problems (severe spine abnormality, sciatica, prior back surgery, spine fracture in the past 3 months); * musculoskeletal problems that limit the ability to walk on a treadmill or ride a stationary bicycle; * Presence of any absolute contraindications to exercise testing and training, as defined by the American College of Sports Medicine. * Practiced or attended any of the following in the prior 3 months: * Yoga, tai chi, qi gong, or meditation more than one time per week on average; * Aerobic exercise (more than 30 minutes a day on at least 3 days a week); * Inability to achieve 85% of heart rate reserve (HRR; the difference between maximum heart rate and resting heart rate) on graded exercise treadmill test. * Severe allergy to soy (defined as life-threatening reaction to soy that would require medical intervention). * Allergy or sensitivity to fish. * Currently eating 4 or more servings of fish per week. * Currently taking an omega-3 fish oil supplement more than twice per week in the past 4 weeks and unwilling to stop for 12 weeks. Interest women can stop all omega-3 supplements and reevaluate eligibility 4 weeks after stopping the omega-3 supplements.