The purpose of this study is to investigate the prevalence of cardiac disease/coronary artery disease and diagnostic yield of different non-invasive methods in patients with type 2 diabetes 40-75 years of age at examination. Exercise tests, Doppler echocardiographic examination with Tissue Velocity Imaging, stress Echocardiography, transthoracic Doppler of coronary arteries with coronary flow reserve, and cardiac MRI with late enhancement at rest, and perfusion after vasodilatation stress will be used in the study. A subpopulation will in addition measure forearm vasodilation(FMD) and CFR before and after 4 months of exercise training.
Study Type
OBSERVATIONAL
Enrollment
104
Diagnostic non-invasive tests:Dopplerechocardiography, cardiac MRI
Volda Hospital HF
Volda, Norway
Prevalence of cardiac abnormalities/disease according to different examination modalities
Time frame: at primary examination
Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI.
Descriptive study; that is at baseline examination except substudy training group which will also be examined after 4 months of exercise training
Time frame: at baseline
Relationship between CFR in LAD and forearm FMD
Relationship between CFR in LAD and forearm FMD before and after 4 months of exercise training in diabetics. Substudy
Time frame: 4 months
Doppler echocardiographic findings related to clinical, laboratory and MRI findings
Special emphasis on new modalities as strain/strain rate at rest and stress. At baseline examination (no follow up)
Time frame: at baseline
Feasibility of transthoracic coronary Doppler examination/Coronary Flow Reserve, and diagnostic yield related to MRI
in exercise training group
Time frame: 4 months
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