Prediction of Pain in Total Knee Arthroplasty

Hvidovre University Hospital100 enrolled

Overview

In this consecutive, prospective cohort study trial the investigators evaluate if preoperative pain response upon heat stimulation is predictive for acute and subacute postoperative pain after total knee arthroplasty.

The preoperative heat stimulation consists of short and long tonic heat stimulation. Pain response is evaluated with an electronic visual analog scale. Furthermore the investigators evaluate other factors possibly predictable for acute and subacute postoperative pain after total knee arthroplasty - demographic factors, preoperative pain related factors, psychosocial factors (Hospital Anxiety and Depression Scale and Pain Catastrophizing Scale).

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Pain, Postoperative

Interventions

Preoperative heat stimulationPROCEDURE

Preoperative short and long tonic heat stimulation

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Ethnic danes, above 18 years and able to give informed consent scheduled for primary, unilateral total knee arthroplasty. Exclusion Criteria: * Bilateral / revision arthroplasty * Disease affection central or peripheral nerve function * Alcohol and medical abuse * Daily use of opioids or glucocorticoids * Malignancy * BMI \> 40 * Depression * Dementia or other cognitive dysfunction

Locations (1)

Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

Outcomes

Primary Outcomes

Cumulated pain (from 0-24 hours after surgery)

Pain during walk 5 m (VAS)

Time frame: 24 hours

Secondary Outcomes

Cumulated pain (from day 1 to day 7 after surgery)

Time frame: 7 days

Pain at day 14 after surgery

Time frame: 14 days

Pain at day 30 after surgery

Time frame: 30 days

Data from ClinicalTrials.gov

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