Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)

Hospital Clinic of Barcelona156 enrolled

Overview

The aim of this study was to compare the response to cardiac resynchronization therapy when the interventricular pacing interval was optimized by Tissue Doppler Imaging (TDI) to response when it was optimized following QRS width criteria.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

156

Conditions

Heart Failure Cardiac Resynchronization Therapy

Interventions

Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curvesDEVICE

Electrocardiographic optimization of the interventricular pacing delay according to QRS widthDEVICE

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients submitted to de novo implant due to conventional cardiac resynchronization therapy indications. Exclusion Criteria: \-

Locations (1)

Hospital Clinic Universitari

Barcelona, Catalonia, Spain

Outcomes

Primary Outcomes

6-month echocardiographic response

Reduction of the end-systolic volume (measured in mililiters according to transthoracic echocardiography) of \>10% as compared to the baseline value.

Secondary Outcomes

6-month clinical response

Combined end-point consisting in no death due to cardiovascular reasons, no heart transplantation and distance increase of \>10% (measured in meters) in the 6-minute walking test.

Data from ClinicalTrials.gov

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