The purpose of this study is to assess the effect of probiotics in childhood recurrent abdominal pain. Patients will be randomly assigned to receive L. reuteri or placebo for 4 weeks with a follow up phase of additional 4 weeks.
Prospective randomized double-blind placebo-controlled trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
101
Daily oral supplementation for four weeks
Placebo administration
Soroka Medical Center
Beersheba, Israel
Frequency and intensity of abdominal pain
Number of pain episodes and pain intensity based on a visual scale
Time frame: Eight weeks
School absenteeism
Number of patients with school absenteeism
Time frame: Eight weeks
Other gastrointestinal symptoms
Any gastrointestinal symptom such as nausea, vomiting, diarrhea, bloating
Time frame: Eight weeks
Adverse effects related to treatment
Any adverse effects related to the probiotic supplementation
Time frame: Eight weeks
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