The aim of the present study is to compare the response to cardiac resynchronization therapy (CRT) in patients with chronic advanced heart failure and permanent atrial fibrillation (AF) depending on atrio ventricular junction (AVJ) is ablated or not.
Cardiac resynchronization therapy (CRT) improves the functional capacity and the quality of life and reduces the mortality of patients with dilated cardiomyopathy, low ejection fraction and wide QRS. Only 2% of patients included in CRT randomized trials were in AF. To obtain a good response to CRT, percentage \>90% of ventricular pacing must be obtained. Based on observational studies, current guidelines of CRT recommend the atrio ventricular junction (AVJ) ablation in those patients with permanent atrial fibrillation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
60
Atrioventricular junction ablation by using radiofrequency energy.
Ventricular rate control by using drug treatment.
Hospital Clinic de Barcelona
Barcelona, Barcelona, Spain
Left ventricular reverse remodelling in cardiac resynchronization therapy and atrial fibrillation.
Comparison of echocardiographic responders in patients with permanent atrial fibrillation submitted to cardiac resynchronization therapy depending on whether the atrio-ventricular junction is ablated or not. Echocardiographic response was defined as left ventricular end-systolic volume reduction \>10%.
Time frame: 1-year follow-up
Clinical response to Cardiac resynchronization therapy.
Comparison of clinical response in patients with permanent atrial fibrillation submitted to cardiac resynchronization therapy, depending on whether the atrio-ventricular junction has been ablated or not. Clinical response is defined as not death/heart transplantation and improvement of the distance walked in the 6-minute walking test \>10%.
Time frame: 1-year follow-up
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