Breath Analysis for Evaluation of Radiation Exposure in Lung Cancer Patients Treated With Radiation

Stanford University20 enrolled

Overview

Patients treated with radiation therapy for lung tumors can experience inflammation after treatment. This study hopes to evaluate the use of breath analysis to evaluate changes in the composition of exhaled breath in patients undergoing radiotherapy. If changes can be detected, this may ultimately serve as biomarkers for identifying patients at highest risk for radiation-induced lung injury (radiation pneumonitis).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lung Cancer Non-Small Cell Lung Cancer Small Cell Lung Cancer

Interventions

Exhaled Breath SamplingPROCEDURE

Standard of care

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of any type of lung tumor * Medical recommendation (independent of the study) that the patient undergo thoracic radiation therapy. Radiation therapy may be either fractionated or hypofractionated (i.e. radiosurgery) * Age \>= 18 years old * Any gender and any ethnic background will be recruited * Capable of giving written informed consent Exclusion Criteria: * Inability of giving written informed consent * Pregnancy or breast-feeding

Locations (1)

Stanford University School of Medicine

Stanford, California, United States

Outcomes

Primary Outcomes

Pre and post-radiation FeNO (fraction of exhaled nitric oxide) measurements

Time frame: Every 3 months for 1 year

Secondary Outcomes

Pre and post-radiation CO (carbon monoxide), CO2 (carbon dioxide), and N2O (nitrous oxide) measurements and feasibility as the fraction of patients unable to give a breath sample. Adverse events are not expected but any that appear related to the breath

Time frame: 1 yr

Data from ClinicalTrials.gov

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