Fabry and Stroke Epidemiological Protocol (FASEP): Risk Factors In Ischemic Stroke Patients With Fabry Disease

University of Rostock1,000 enrolled

Overview

More than one million people in Europe suffer from a stroke every day. Normally older people have a stroke, but also a significant number of younger people between 18 and 55 years. Usually, these can only be explained for a minority by the classical risk factors such as diabetes, overweight and high blood pressure. New studies indicate that in about 1 - 2 % of the younger stroke patients the etiology can be an undiagnosed genetic disease, e.g. Fabry disease. Fabry disease is a lysosomal storage disorder known to cause vasculopathy. The purpose of this study is to determine in a large number of young stroke patients, how many strokes were caused by Fabry disease and what risk factors might be able to predict this disease.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Cerebrovascular Accident Stroke, Acute Cerebral Stroke

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (18 - 60 years of age) with an acute ischemic cerebrovascular event either acute ischemic stroke or transient ischemic attack within 10 days * Diagnosis of the cerebrovascular event (CVE) by a stroke experienced physician * Diagnostic procedures for CVE according to the local guidelines and recommendations * Written informed consent from patient or legal representative according to local regulations Exclusion Criteria: * Patients being younger than 18 years or older than 60 years of age. * Acute ischemic stroke or transient ischemic attack longer than 10 days before enrollment into the study * CVE associated with intracranial hemorrhage as evidenced by cerebral CT scan * Any uncertainty in the diagnosis * No written informed consent from the patient or legal representative

Locations (14)

Department of Neurology, Kreiskrankenhaus Altenburg

Altenburg, Germany

Dept. of Neurology, Vivantes Netzwerk für Gesundheit GmbH, Klinikum Neukölln

Berlin, Germany

Department of Neurology, Allgemeines Krankenhaus Celle

Celle, Germany

Department of Neurology, Klinikum Chemnitz gGmbH

Chemnitz, Germany

Heinrich-Heine University Duesseldorf, Dept. of Neurology

Düsseldorf, Germany

Universitätsklinikum Giessen, Department of Neurology

Giessen, Germany

Department of Neurology S10, Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

Universität Heidelberg, Klinik für Neurologie

Heidelberg, Germany

Department of Neurology, Universitaetsklinikum Jena

Jena, Germany

Dept. of Neurology, Ökumenisches Hainich Klinikum gGmbH

Mühlhausen / Thürigen, Germany

...and 4 more locations