Trial Comparing Two Techniques of Celiac Plexus Neurolysis for Treatment of Pain in Carcinoma Pancreas

Asian Institute of Gastroenterology, India100 enrolled

Overview

Coeliac plexus neurolysis (CPN) is a management option for pain control in carcinoma pancreas.CPN is conventionally performed by percutaneous technique with fluoroscopic guidance. Endoscopic ultrasound (EUS) is increasingly used for CPN as it offers a better visualization of the plexus. There are limited data comparing the two modalities.The patients are on follow-up for 6 months post neurolysis.

Carcinoma pancreas patients with abdominal pain requiring daily analgesics for more than 4 weeks were included.we are randomising about 100 patients into two groups to undergo either of the two procedures, i.e. celiac plexus neurolysis by percutaneous technique or by endoscopic ultrasound guided technique.The pain scores have been recorded by visual analogue scale for an average follow-up of 6 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Pancreatic Cancer

Interventions

percutaneous fluoro guided celiac plexus neurolysisPROCEDURE

It is percutaneous injection of neurolytic agent in and around the celiac ganglion

EUS guided neurolysisPROCEDURE

It is injection of neurolytic agent in and around the celiac ganglion using an echo endoscope.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * all patients with carcinoma pancreas Exclusion Criteria: * patients below 18 years of age and who have not given consent

Locations (1)

Asian Institute of Gastroenterology

Hyderabad, Andhra Pradesh, India

RECRUITING

Outcomes

Primary Outcomes

immediate pain relief

Time frame: day of block to six months of follow-up

Data from ClinicalTrials.gov

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