A Safety and Tolerability Study of Administration of PSD502

Inclusion Criteria: * Female non-smokers aged 18 years old and over * Willing and able to provide written informed consent * Generally, in good health in the opinion of the investigator * Subject must have a body mass index between 18 and 30 kg/m2, inclusive * Willing and able to comply with all study procedures in the opinion of the investigator * Negative Papanicolaou smear performed either during gynaecological examination at screening or documented in the 12 months prior to study entry * Negative drugs of abuse and cotinine test at screening * Female subjects of child-bearing potential who are sexually active or become sexually active must be using a method of effective contraception from 14 days before screening and continue to use this until the end of the study (If oral contraceptives are used, these must have been stable for a period of 3 months. If a barrier method is being used, this should be latex based and not polyurethane based) * Female subjects who are post-menopausal must have been post-menopausal \>1 year and have confirmed elevated serum follicle stimulating hormone at screening Exclusion Criteria: * History of a significant medical condition that would preclude further study participation, in the opinion of the investigator * Currently taking, or has taken within the 2 weeks prior to screening, any concomitant medication that could confound interpretation of the safety or pharmacokinetic data on PSD502. Use of prescription medication within 14 days or over-the-counter products within 7 days prior to first dose * Suffering from an sexually transmitted disease, or is positive for hepatitis B, hepatitis C, or human immunodeficiency virus infection * Safety testing: abnormalities at screening, in particular liver function tests, which are indicative of a medical condition and that would preclude further participation, in the opinion of the investigator * Significant abnormality of the vaginal mucosa or cervix that would preclude interpretation of the examination of these areas or that could be worsened by use of PSD502 * History of alcohol or drug abuse within 1 year prior to screening * Known drug sensitivity to amide-type local anaesthetics * Unlikely to understand or be able to comply with study procedures, for any reason, in the opinion of the investigator * History of glucose-6-phosphate dehydrogenase deficiency or use of medications that would increase susceptibility to methemoglobinemia (e.g., anti-malarial agents) * Use of class I (e.g., mexiletine, tocainide) and III (e.g., amiodarone, sotalol) anti-arrhythmic drugs * Subject has received an investigational (non-registered) drug within 90 days of screening * Subject has any physical or psychological condition that would prevent them from undertaking the study procedures, including, but not limited to, the following: * Uro-gynaecological disease or recent surgery within 8 weeks of screening which would make intravaginal application or vaginal examination/colposcopy difficult or painful OR * Ongoing significant psychiatric disorder (e.g., bipolar disease, depression/anxiety disorder or schizophrenia) * Subject has a clinically obvious vaginal infection, such as active vaginal Candida albicans (thrush), or other abnormal vaginal discharge * Subjects who are pregnant or lactating * Subjects should not be menstruating during the treatment phase * Subjects who refuse to allow their primary care physician to be informed of their participation * Donation of blood or blood products within 90 days prior to dosing or at any time during the study, except as required by this protocol