Trisenox® in Women With Metastatic Endometrial Cancer

Inclusion Criteria: 1. ≥18 years of age with histologically confirmed metastatic or recurrent endometrial cancer 2. Documented progression of their endometrial cancer (i.e., within the last 3 months) 3. If of childbearing potential they must agree to use approved barrier methods of contraception 4. Presence of at least one measurable lesion that: * Can be accurately measured in at least one dimension with longest diameter ≥20 mm using conventional techniques or ≥10 mm with spiral CT scan (or otherwise at least twice the reconstruction interval for CT or MRI scans). * Previously irradiated lesions may be considered to be measurable provided: 1) there has been documented progression of the lesion(s) since completion of radiotherapy, and 2) the criteria for measurability as outlined above are met. 5. Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 6. Minimum life expectancy of 3 months 7. Adequate renal and hepatic function (per study protocol guidelines) 8. Adequate bone marrow function (per study protocol guidelines) 9. Serum cholesterol \<350 mg/dL and triglycerides \< 400 mg/dL 10. Able to understand and give written informed consent 11. Ejection fraction \>55% with no focal left ventricular wall motion abnormalities in patients with a history of coronary artery disease or a history of congestive heart failure. Exclusion Criteria: 1. Women who are pregnant or lactating 2. Presence of brain metastases 3. Two or more prior cycles of cytotoxic chemotherapy since recurrence (Two total regimens are allowed if one includes adjuvant therapy.) 4. Prior therapy with Trisenox or known sensitivity to this agent 5. Prior anticancer treatment (chemotherapy, radiotherapy, immunotherapy, biological response modifiers, signal transduction inhibitors, etc) within 4 weeks prior to the first dose of Trisenox. 6. Ongoing toxicity associated with prior anticancer therapy (except peripheral neuropathy of ≤ grade 1 by NCI toxicity criteria) 7. Another primary malignancy within the past three years (except for non-melanoma skin cancer and cervical carcinoma in situ) 8. Significant uncontrolled cardiovascular disease 9. Active infection requiring systemic therapy 10. Known HIV infection 11. Treatment with any investigational agent within 4 weeks prior to the first dose of Trisenox 12. Concurrent treatment with immunosuppressive agents other than prescribed corticosteroids 13. Inadequate recovery from any prior surgical procedure or having undergone any major surgical procedure within 2 weeks prior to the first dose of Trisenox 14. Patients having undergone recent placement of a central venous access port will be considered eligible if they have recovered 15. Presence of any other life-threatening illness or organ system dysfunction which, in the opinion of the Investigator, would either compromise the patient's safety or interfere with evaluating the safety of the study drug 16. Prolonged absolute corrected QT interval (QTc) interval \> 500 msec 17. Underlying conduction disease that prevents measurement of QT interval 18. History of ventricular tachycardia or any cardiac arrhythmia requiring the placement of an automated intraventricular cardiac defibrillator. 19. Inability to discontinue therapy with class I or class III antiarrhythmic medications. 20. Inability to discontinue drugs known to be associated with a risk for torsades de pointes