Cognitive disorders in patients underwent general anesthesia are discussed for decades, but whether there were precise relationship between general anesthesia and dysgnosia is yet to be guaranteed. Although controversial data reported from experimental studies in animals, the investigators still proposed that general anesthetics could impair the normally organized system of the central nervous system, which finally displayed a dysfunction of cognition after general anesthesia in a short- or long-term period. Therefore, different types of general anesthetics such as inhalational anesthetics and intravenous anesthetics, the investigators hypothesized, had a long-term influence on patients' cognitive ability.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
10,000
1-8% sevoflurane for maintaining the whole period of general anesthesia
1-4 mg/kg/h of propofol during the whole period of general anesthesia
Nanjing Maternity and Child Health Care Hospital
Nanjing, Jiangsu, China
RECRUITINGCognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: The 10th year since postoperation
Cognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: One hour before operation
Cognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: Immediately after operation (0 day)
Cognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: One month after operation
Cognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: Six month after operation
Cognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: One year after operation
Cognitive ability
Cognitive ability will be assessed with digital lignature game, figure identificaiton, and recall memory
Time frame: Once a year from the 1st year after operation up to 9th year
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