Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda

University of California, San Francisco

Overview

The effectiveness of sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment in pregnancy in malaria-endemic areas the effectiveness and efficacy of SP may be compromised by increased SP resistance. This study will evaluate the efficacy of SP by giving SP to asymptomatic parasitemic pregnant women and following them to determine the rates of parasite clearance.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Conditions

Intermittent Preventive Treatment Placental Malaria

Interventions

Sulfadoxine-pyrimethamineDRUG

Sulfadoxine-pyrimethamine tablets, once

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * 16-26 weeks gestation based on LMP or ultrasound or fundal height * Axillary temperature \<37.5 degrees C * Informed consent * HIV status known and negative * Blood smear positive for falciparum malaria Exclusion Criteria: * History of hypersensitivity reaction to SP or components of SP * Axillary temperature ≥37.5 degrees C * History of receipt of antimalarials or antibiotics with antimalarial activity\* in the past month * Residence \> 30 km from the ANC clinic or unwillingness to return for follow-up visits * Hemoglobin level \< 5 gm/dL * These medications include all antimalarials, rifampin, doxycycline, clindamycin, tetracycline, erythromycin, azithromycin, chloramphenicol.

Locations (1)

Infectious Disease Research Center

Tororo, Tororo, Uganda

Outcomes

Primary Outcomes

Parasite clearance

Clearance of parasites in pregnant women with asymptomatic parasitemia after administration of SP

Time frame: 42 days

Data from ClinicalTrials.gov

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